| Place Name | Depew |
| Place Type | Village |
| ZIP Code(s) | 14043 |
| County | Erie County |
| Area Code(s) | 716 |
| Timezone | Eastern Daylight Time (EDT) |
| Population (2022) | 15,324 |
| Population Growth Rate (2010-19) | -0.82% |
| Majority Ethnicity | White 91.97% |
| Metro/Micro Stats Area | Buffalo-Cheektowaga, NY |
| US Congressional District(s) | New York 26thNew York 27th |
| State Assembly Districts | 143 |
| State Senate Districts | 59,63 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 91.97% |
| African American | 4.28% |
| Hispanic | 0.05% |
| Asian | 0.44% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 3.26% |