| District Name | De Soto 73 School District |
| State | Missouri |
| County | Jefferson County Saint Francois County Ste Genevieve County |
| Statistical Area | St. Louis, MO-IL:st-louis-mo-il St. Louis, MO-IL:st-louis-mo-il |
| Total Students (2021) | 2603 |
| District Growth Rate (2017-21) | -13.9% |
| Majority Race/Ethnicty | White (94.3%) |
| Free/Reduced Lunch Program | 47.14% |