| District Name | Sikeston R-VI School District |
| State | Missouri |
| County | Scott County New Madrid County |
| Statistical Area | Sikeston, MO |
| Total Students (2021) | 3338 |
| District Growth Rate (2017-21) | -3.3% |
| Majority Race/Ethnicty | White (53.0%) |
| Free/Reduced Lunch Program | 74.63% |