| Place Name | Matlacha Isles-Matlacha Shores |
| Place Type | Census Designated Place |
| ZIP Code(s) | 33991 33993 |
| County | Lee County |
| Area Code(s) | 239 |
| Timezone | Eastern Standard Time (EST) |
| Population (2022) | 360 |
| Population Growth Rate (2010-19) | -0.87% |
| Majority Ethnicity | White 100% |
| Metro/Micro Stats Area | Cape Coral-Fort Myers, FL |
| US Congressional District(s) | Florida 19th |
| State House Districts | 77 |
| State Senate Districts | 27 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 100% |
| African American | 0% |
| Hispanic | 0% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 0% |