| Place Name | De Soto |
| Place Type | Census Designated Place |
| ZIP Code(s) | 39355 39360 |
| County | Clarke County |
| Area Code(s) | 601,769 |
| Timezone | Central Standard Time (CST) |
| Population (2022) | 261 |
| Majority Ethnicity | White 53.44% |
| Metro/Micro Stats Area | Meridian, MS |
| US Congressional District(s) | Mississippi 3rd |
| State House Districts | 84 |
| State Senate Districts | 33 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 53.44% |
| African American | 46.56% |
| Hispanic | 0% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 0% |