| Place Name | Holy Cross |
| Place Type | City |
| ZIP Code(s) | 99602 |
| County | Yukon-Koyukuk Census Area |
| Area Code(s) | 907 |
| Timezone | Alaska Standard Time (AKST) |
| Population (2022) | 183 |
| Population Growth Rate (2010-19) | -1.12% |
| Majority Ethnicity | Native American 0% |
| US Congressional District(s) | Alaska At-Large |
| State House Districts | 37 |
| State Senate Districts | S |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 3.39% |
| African American | 0% |
| Hispanic | 92.88% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 3.73% |