| Place Name | De Soto |
| Place Type | City |
| ZIP Code(s) | 63020 |
| County | Jefferson County |
| Area Code(s) | 636 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 6,440 |
| Population Growth Rate (2010-19) | 0.77% |
| Majority Ethnicity | White 97.17% |
| Metro/Micro Stats Area | St. Louis, MO-IL |
| US Congressional District(s) | Missouri 8th |
| State House Districts | 118 |
| State Senate Districts | 3 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 97.17% |
| African American | 0.93% |
| Hispanic | 0.27% |
| Asian | 0.37% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 1.26% |