| Place Name | Osceola |
| Place Type | City |
| ZIP Code(s) | 64776 |
| County | Saint Clair County |
| Area Code(s) | 417 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 1,056 |
| Population Growth Rate (2010-19) | -4.01% |
| Majority Ethnicity | White 90.51% |
| US Congressional District(s) | Missouri 4th |
| State House Districts | 125 |
| State Senate Districts | 28 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 90.51% |
| African American | 2.91% |
| Hispanic | 1.03% |
| Asian | 0.68% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 4.87% |