| Place Name | Prairie Home |
| Place Type | City |
| ZIP Code(s) | 65068 |
| County | Cooper County |
| Area Code(s) | 660 |
| Timezone | Central Standard Time (CST) |
| Population (2022) | 247 |
| Population Growth Rate (2010-19) | -6.43% |
| Majority Ethnicity | White 100% |
| Metro/Micro Stats Area | Columbia, MO |
| US Congressional District(s) | Missouri 4th |
| State House Districts | 50 |
| State Senate Districts | 19 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 100% |
| African American | 0% |
| Hispanic | 0% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 0% |