| Place Name | Sikeston |
| Place Type | City |
| ZIP Code(s) | 63801 |
| County | Scott County New Madrid County |
| Area Code(s) | 573 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 16,414 |
| Population Growth Rate (2010-19) | -0.17% |
| Majority Ethnicity | White 71.2% |
| Metro/Micro Stats Area | Sikeston, MO |
| US Congressional District(s) | Missouri 8th |
| State House Districts | 148,149 |
| State Senate Districts | 25,27 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 71.2% |
| African American | 24.85% |
| Hispanic | 0.04% |
| Asian | 0.79% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 3.11% |