| Place Name | Port Isabel |
| Place Type | City |
| ZIP Code(s) | 78578 |
| County | Cameron County |
| Area Code(s) | 956 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 5,041 |
| Population Growth Rate (2010-19) | 0.44% |
| Majority Ethnicity | White 50.97% |
| Metro/Micro Stats Area | Brownsville-Harlingen, TX |
| US Congressional District(s) | Texas 34th |
| State House Districts | 37 |
| State Senate Districts | 27 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 50.97% |
| African American | 0% |
| Hispanic | 0.18% |
| Asian | 0.81% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 48.04% |