| Place Name | Mayersville |
| Place Type | Town |
| ZIP Code(s) | 39113 |
| County | Issaquena County |
| Area Code(s) | 662 |
| Timezone | Central Daylight Time (CDT) |
| Population (2022) | 665 |
| Population Growth Rate (2010-19) | -20.84% |
| Majority Ethnicity | African American 94.79% |
| US Congressional District(s) | Mississippi 2nd |
| State House Districts | 50,54 |
| State Senate Districts | 23 |
| Race/Ethnicy | Percentage of Population (2021) |
|---|---|
| White | 5.21% |
| African American | 94.79% |
| Hispanic | 0% |
| Asian | 0% |
| Native American | 0% |
| Hawaiin/Pacific Islander | 0% |